DYNAMIC CONTRAST ENHANCED MRI METHOD AND AGENTS FOR THE ASSESSMENT OF THE MACROMOLECULAR TRANSPORT WITHIN PATHOLOGIC TISSUES

摘要

The present invention generally relates to paramagnetic contrast agents and a Dynamic Contrast Enhanced-MRI method for the non-invasive estimation of the delivery of a macromolecular anticancer drug or pro-drug within pathological tissues and, especially, in solid tumors and for the optimization of anticancer therapies.