The present invention relates to the crystal structure of the insulin receptor ectodomain, to the nature of its N-linked glycans and to methods of using the crystal and related structural information to screen for and design compounds that interact with or modulate the insulin receptor and/or the closely-related insulin-like growth factor receptors or variants thereof.
申请公布号
AU2007262666(B2)
申请公布日期
2013.09.12
申请号
AU20070262666
申请日期
2007.06.22
申请人
WALTER AND ELIZA HALL INSTITUTE OF MEDICAL RESEARCH
发明人
GARRETT, THOMAS P. J.;LOVRECZ, GEORGE;LAWRENCE, MICHAEL COLIN;LOU, MEIZHEN;MCKERN, NEIL MORETON;ADAMS, TIMOTHY EDWARD;SPARROW, LINDSAY GALE;STRELSTOV, VICTOR;WARD, COLIN WESLEY