发明名称 |
METHODS OF TREATING AND PREVENTING THROMBOTIC DISEASES USING ASK1 INHIBITORS |
摘要 |
A method of treating or preventing a thrombotic disease in a subject in need thereof comprises administering to the subject an effective amount of a pharmaceutical composition comprising an inhibitor of an apoptosis signal regulating kinase 1 (ASK1) protein. A method of identifying an inhibitor of an apoptosis signal regulating kinase 1 (ASK1) protein useful for treating or preventing a thrombotic disease, comprising (a) contacting a candidate agent with a test sample comprising the ASK1 protein, and (b) comparing the ASK1 protein activity in the test sample with the ASK1 protein activity in a control sample that has not been contacted with the candidate agent, whereby a decrease in the ASK1 protein activity in the test sample compared with the control sample indicates that the candidate agent is an ASK1 inhibitor.
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申请公布号 |
US2013236441(A1) |
申请公布日期 |
2013.09.12 |
申请号 |
US201113988127 |
申请日期 |
2011.11.18 |
申请人 |
NAIK ULHAS P.;NAIK MEGHNA U.;UNIVERSITY OF DELAWARE |
发明人 |
NAIK ULHAS P.;NAIK MEGHNA U. |
分类号 |
A61K38/46;A61K38/00;A61K38/45;C12Q1/48 |
主分类号 |
A61K38/46 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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