| 摘要 |
Provided are a superior dipeptidyl peptidase-IV inhibitor and the like. Specifically provided is a peptide comprising the sequence Val-Pro-X (therein, X represents an amino acid residue other than an L-proline residue). Preferably, the group represented by X is selected from among residues of basic amino acids, neutral aliphatic amino acids, neutral amino acids having an amide group, and neutral aromatic amino acids. More preferably, the group represented by X is selected from among the residues of alanine, glutamine, methionine, asparagine, glycine, valine, tyrosine, serine and lysine. Also provided are a dipeptidyl peptidase-IV inhibitor, a hypoglycemic agent, a vascular endothelial dysfunction inhibitor, and an angiotensin-converting enzyme inhibitor, each comprising said peptide as an active ingredient. |
