发明名称 |
Crystalline D-isoglutamyl-D-tryptophan and the mono ammonium salt of D-isoglutamyl- D-tryptophan |
摘要 |
A process for making pure crystalline D-isoglutamyl-D-tryptophan is provided which includes the step of deprotecting essentially pure N-tert-butoxycarbonyl-D- isoglutamyl-D-tryptophan or its diester to yield essentially pure D-isoglutamyl-D- tryptophan. A process is also provided for the preparation of pure mono ammonium salt of D-isoglutamyl-D-tryptophan from essentially pure N-tert-butoxycarbonyl-D- isoglutamyl-D-tryptophan. D-isoglutamyl-D-tryptophan, ammonium salt (1 :1) is a stable pharmaceutical solid. |
申请公布号 |
AU2007327344(B2) |
申请公布日期 |
2013.09.12 |
申请号 |
AU20070327344 |
申请日期 |
2007.11.26 |
申请人 |
APOTEX TECHNOLOGIES INC. |
发明人 |
TAM, TIM FAT;YU, LILY;WANG, YINGSHENG;N'ZEMBA, BLAISE;ZHAO, YANQING;LEUNG-TOUNG, REGIS |
分类号 |
C07K1/107;A61K38/05;A61P17/06;C07K1/16;C07K1/30;C07K5/02;C07K5/037;C07K5/06;C30B7/14 |
主分类号 |
C07K1/107 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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