| 发明名称 |
NOVEL COMPOUNDS THAT ARE ERK INHIBITORS |
| 摘要 |
Disclosed are the ERK inhibitors of formula (1): and the pharmaceutically acceptable salts thereof, wherein: A is a five membered monocyclic heteroaryl ring; and B is a monocyclic heterocycloalkyl ring, or a monocyclic heterocycloalkenyl ring, or a bridged monocyclic heterocycloalkyl ring, or a fused (monocyclic heterocycloalkyl ring) cyclopropyl ring. Also disclosed are methods of treating cancer using the compounds of formula (1).
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| 申请公布号 |
US2013237518(A1) |
申请公布日期 |
2013.09.12 |
| 申请号 |
US201113881050 |
申请日期 |
2011.10.24 |
| 申请人 |
BOGA SOBHANA BABU;KELLY JOSEPH M.;ZHU HUGH Y.;ALHASSAN ABDUL-BASIT;YAO XIN;GAO XIAOLEI;WANG JAMES J-S;DESAI JAGDISH A.;GUDIPATI SUBRAHMANYAM;LO SIE-MUN;ZHU LIANG;COOPER ALAN B.;DENG YONGQI;SHIPPS, JR. GERALD W.;MERCK SHARP & DOHME CORP |
发明人 |
BOGA SOBHANA BABU;KELLY JOSEPH M.;ZHU HUGH Y.;ALHASSAN ABDUL-BASIT;YAO XIN;GAO XIAOLEI;WANG JAMES J-S;DESAI JAGDISH A.;GUDIPATI SUBRAHMANYAM;LO SIE-MUN;ZHU LIANG;COOPER ALAN B.;DENG YONGQI;SHIPPS, JR. GERALD W. |
| 分类号 |
C07D401/14;A61K31/444;A61K31/454;A61K31/4545;A61K31/5377;A61K45/06;C07D405/14;C07D409/14;C07D413/14;C07D417/14;C07D471/04 |
主分类号 |
C07D401/14 |
| 代理机构 |
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