| 摘要 |
The present invention relates to a pharmaceutical composition for treating visceral leishmaniasis, characterized in that it comprises the association of conventional liposomes and prolonged-circulation liposomes with a leishmanicidal-drug delivery system. Said composition may be used in the preparation of a medicinal product for treating leishmaniasis and may be administered intramuscularly, subcutaneously, intraperitoneally or intravenously. The use of this system enables the drug efficiently to reach all sites infected by the parasite, the pegylated liposomes promoting more effective targeting of the leishmanicidal drugs on the bone marrow and spleen, whilst the conventional liposomes contribute to the targeting of the drug on the liver. |
| 申请人 |
UNIVERSIDADE FEDERAL DE MINAS GERAIS - UFMG;FUNDACAO DE AMPARO A PESQUISA DO ESTADO DE MINAS GERAIS - FAPEMIG;JEAN GEORGES FREZARD, FREDERIC;GUILHERME AZEVEDO, ERLY;RIO RIBEIRO, RAUL;PERES DEMICHELI, CYNTHIA;MAGNO DA SILVA, SYDNEI;APARECIDA REZENDE, SIMONE |
发明人 |
JEAN GEORGES FREZARD, FREDERIC;GUILHERME AZEVEDO, ERLY;RIO RIBEIRO, RAUL;PERES DEMICHELI, CYNTHIA;MAGNO DA SILVA, SYDNEI;APARECIDA REZENDE, SIMONE |
