发明名称 |
SYNTHESIS AND MICRO-/NANOSTRUCTURING OF SURFACE-ATTACHED CROSSLINKED ANTIMICROBIAL AND/OR ANTIBIOFOULING POLYMER NETWORKS |
摘要 |
The present invention relates to substrates comprising a crosslinked network of covalently attached antimicrobial and/or antibiofouling polymers. The crosslinked network of antimicrobial and/or antibiofouling polymers acts highly efficiently against pathogens, e.g. bacteria and fungi. Both the antimicrobial and the antibiofouling cross-linked polymer networks are preferably better resistant to mechanical damage than simple surface-immobilized polymer monolayers. The antimicrobial and/or antibiofouling polymers of the crosslinked network are preferably obtained by ring opening metathesis polymerization (ROMP) and exhibit a molecular weight of preferably more than 30,000 or even 100,000 g mol-1. The crosslinked network of antimicrobial and/or antibiofouling polymers is preferably covalently attached to the surface of a substrate, e.g. an implant, a medical device, medical equipment or a (tissue-supporting) biomaterial, etc. The present invention is also directed to uses of crosslinked networks of antimicrobial and/or antibiofouling polymers as defined herein, e.g. for coating a surface of a substrate, and to methods therefore. |
申请公布号 |
WO2013132066(A2) |
申请公布日期 |
2013.09.12 |
申请号 |
WO2013EP54734 |
申请日期 |
2013.03.08 |
申请人 |
UNIVERSITAETSKLINIKUM FREIBURG;ALBERT-LUDWIGS-UNIVERSITAET FREIBURG |
发明人 |
LIENKAMP, KAREN, DR.;BELARDI, JAKOB;ZOU, PENG;AL-AHMAD, ALI;STEINBERG, THORSTEN, ASSOC. PROF. DR.;TOMAKIDI, PASCAL, PROF. DR. |
分类号 |
C08G61/12 |
主分类号 |
C08G61/12 |
代理机构 |
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