发明名称 |
USE OF APL-TYPE PEPTIDE FOR TREATING INTESTINAL INFLAMMATORY DISEASES AND TYPE 1 DIABETES |
摘要 |
<p>The present invention is related with the field of the medicine, particularly with the use of an APL peptide or its analogues derived from the human heat shock protein of 60 kDa, for the manufacture of a pharmaceutical composition for the treatment of Crohn's disease, ulcerative colitis and diabetes mellitus type 1. This peptide is biodistributed into the gastrointestinal tract and also promotes the induction of apoptosis in activated intestinal lamina propria and peripheral blood T cells of patients with Crohn's disease. Furthermore, this peptide induces apoptosis in mononuclear cells of patients with diabetes mellitus type 1.</p> |
申请公布号 |
EP2374468(B1) |
申请公布日期 |
2013.09.11 |
申请号 |
EP20090804226 |
申请日期 |
2009.12.29 |
申请人 |
CENTRO DE INGENIERIA GENETICA Y BIOTECNOLOGIA |
发明人 |
BARBERA BETANCOURT, ARIANA;DOMINGUEZ HORTA, MARIA, DEL CARMEN;LORENZO PEREZ, NORAILYS;PADRON PALOMARES, GABRIEL, RAMON;FALCON CAMA, VIVIANA;MENENDEZ VALDES, IVON |
分类号 |
A61K38/17;A61P1/04;A61P3/10 |
主分类号 |
A61K38/17 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|