发明名称 |
PATCH |
摘要 |
Disclosed is a patch which is a formulation including deposited clonidine crystals and provides stable transdermal absorbability even after storage at varying temperatures. The patch disclosed includes a backing and a medicated layer integrally superposed on one surface of the backing. The medicated layer contains: 5 to 30% by weight of clonidine including clonidine in a crystallized state; 25 to 90% by weight of a macromolecular base (A) having a viscosity-average molecular weight of 800,000 or larger; and 5 to 60% by weight of a liquid additive capable of dissolving the clonidine. The weight ratio of the liquid additive to the macromolecular base (A) [the liquid additive/the macromolecular base (A)] is 0.1 to 2.0. |
申请公布号 |
EP2636408(A1) |
申请公布日期 |
2013.09.11 |
申请号 |
EP20110838081 |
申请日期 |
2011.11.02 |
申请人 |
SEKISUI MEDICAL CO., LTD. |
发明人 |
UDAGAWA HIROKO;INABA YOSHIKAZU;NODA YUKIHIKO;OBATA KUMI;TERASHIMA HIROTO |
分类号 |
A61K31/4168;A61K9/70;A61K47/06;A61K47/32;A61P9/12 |
主分类号 |
A61K31/4168 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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