Method for preparing solubilized composition containing oil-soluble substance

摘要

The present invention provides a method for preparing a solubilized composition containing an oil-soluble substance having both acid and heat resistance, including:
the step of dissolving an oil-soluble substance and two or three emulsifiers selected from
(1) an emulsifier E1 comprising an ester of a fatty acid having an HLB of not less than 10 and not more than 14 carbon atoms with a polyglycerol having a polymerization degree of not less than 3,
(2) an emulsifier E2 comprising an ester of a fatty acid having an HLB of not less than 10 and not more than 14 carbon atoms with sucrose, or
(3) an emulsifier E3 comprising lecithin in which phosphatidylcholine accounts for not less than 50% and/or lysolecithin in which lysophosphatidylcholine accounts for not less than 50% of a phospholipid content in (a) ethanol or (b) a mixed solvent of ethanol with at least one selected from the group consisting of acetone, hexane, and ethyl acetate to prepare a transparent solution; and
the step of distilling the solvent off from the transparent solution.