ANALOGUES OF INSULIN-LIKE GROWTH FACTOR-1 (IGF-1) HAVING AMINO ACID SUBSTITUTION AT POSITION 59

摘要

The present invention relates to novel analogues of insulin-like growth factor-1 (IGF-1), pharmaceutical compositions containing said analogues, and the use of said analogues for treatment of IGF-1 - receptor mediated conditions, such as short stature, diabetes therapy, neurodegenerative disease treatment, and cartilage repair. More particularly, the present invention relates to novel analogues of IGF-I having an amino acid substitution at position 59, e.g., (Asn)hIGF-1(1-70)-OH (SEQ ID NO: 1), and other substitution(s) as defined herein.