PROCESS FOR THE PREPARATION OF 5-N-UREIDO-17-{(E)-[(3E)-3-(ARYLIDENE)-2-OXOCYCLOPENTYLIDENE]METHYL}-25,27-DIALKOXY-26,28-DIHYDROXYCALIX[4]ARENES

摘要

A process for the preparation of 5-N-ureido-17-{(E)-[(3E)-3-(arylidene)-2-oxocyclopentylidene]methyl}-25,27-dialkoxy-26,28-dihydroxycalix[4]arenes consists in that 5-nitro-17-formyl-25,27-dipropoxy-26,28-dihydroxycalix [4]arene is condensed with (2E)-2-(arylidene)cyclopentanone in the presence of dimethylammonium dimethylcarbamate (DIMCARB) in chloroform while heating in the temperature range 20-60 °C with formation of 5-nitro-17-{(E)-[(3E)-3-(arylidene)-2- oxocyclopentylidene]methyl}-25,27-dialkoxy-26,28-dihydroxycalix[4]arenes which reduction with hydrazine hydrate in the presence of Raney nickel provides corresponding aminoderivatives that by interaction with isocyanate at room temperature in ether are transformed to end products separated by conventional methods.