发明名称 |
Sterile hyaluronic acid solutions |
摘要 |
Sterilized aqueous solution comprising 0.04% to 0.8% by weight hyaluronic acid with a weight average molecular weight from 0.6 MDa to 3.6 MDa, and one or more buffer components selected from the group consisting of boric acid, sodium borate and sodium dihydrogen phosphate. The aqueous solution also has an ionic strength equivalent to an aqueous concentration of sodium chloride from 4% to 18% by weight of sodium chloride and a pH from 6.4 to 7.2. The solution is also filtered through a filter medium that has an average pore size of 0.25 mum or less to provide a sterilized high salt, hyaluronic acid solution.
|
申请公布号 |
US8530641(B2) |
申请公布日期 |
2013.09.10 |
申请号 |
US201213564161 |
申请日期 |
2012.08.01 |
申请人 |
LIU X. MICHAEL;HEILER DAVID J.;MENZEL THOMAS;BRONGO ABBIE;BURKE SUSAN E.;CUMMINS KARL;BAUSCH & LOMB INCORPORATED |
发明人 |
LIU X. MICHAEL;HEILER DAVID J.;MENZEL THOMAS;BRONGO ABBIE;BURKE SUSAN E.;CUMMINS KARL |
分类号 |
A61K31/728;C08B37/00;C08B37/08 |
主分类号 |
A61K31/728 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|