TUNABLE HYALURONIC ACID-CALCIUM PHOSPHATE COMPLEXES WITH DELIVERY RATE OF GROWTH FACTORS AND PREPARATION METHOD THEREOF

摘要

PURPOSE: A hyaluronic acid-calcium phosphate complex which is able to regulate growth factor delivery rate and a method for preparing the same are provided to properly deliver osteanagenesis-related growth factors because the hyaluronic acid-calcium phosphate complex is prepared using calcium, phosphorus, and hyaluronic acid which exists in an extracellular matrix. CONSTITUTION: A hyaluronic acid-calcium phosphate complex for supporting growth factors comprises: crosslinked hyaluronic acid hydrogel with pores which are connected each other; and calcium phosphate microspheres which are dispersed in the pores and has a size of 45-75 micrometers. A method for preparing the complex comprises the steps of: sintering calcium phosphate powder at 1050-1250°C and preparing the calcium phosphate microspheres with a size of 45-75 micrometers; and mixing the calcium phosphate microspheres with crosslinked hyaluronic acid hydrogel.