发明名称 |
Method of screening for compounds which affect the cleavage of EphA7 bygamma-secretase |
摘要 |
The present invention provides a method of screening for compounds which affect the cleavage of EphA7 by gamma-secretase. The method includes the following steps: (i) contacting a first biological composition containing gamma-secretase or a biologically active fragment thereof with a second biological composition containing EphA7 in the presence and absence of a candidate compound; (ii) measuring the cleavage of the EphA7 in the presence and absence of the candidate compound; (iii) selecting those candidate compounds which affect the cleavage of the EphA7 by gamma-secretase; and (iv) identifying the candidate compounds selected in step (iii) as compounds which affect the cleavage of EphA7 by gamma-secretase.
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申请公布号 |
US8530181(B2) |
申请公布日期 |
2013.09.10 |
申请号 |
US20080742312 |
申请日期 |
2008.11.17 |
申请人 |
INOUE EIJI;EISAI R&D MANAGEMENT CO., LTD. |
发明人 |
INOUE EIJI |
分类号 |
C12Q1/37 |
主分类号 |
C12Q1/37 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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