发明名称 |
High purity 2-[4-(3- OR 2-fluorobenzyloxy)benzylamino]propanamides and methods of use thereof |
摘要 |
A process for obtaining therapeutically active 2-[4-(3- and 2-(fluorobenzyloxy)benzylamino]-propanamides and their salts with pharmaceutically acceptable acids with a high degree of purity, i.e. with a content of dibenzyl derivatives impurities lower than 0.03% by weight. The process is carried out by submitting a Schiff base intermediate to a reduction reaction with a reducing agent in an amount of organic solvent to allow the formation (and presence during a substantial portion of the reduction reaction) of a suspension of the Schiff base.
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申请公布号 |
US8530701(B2) |
申请公布日期 |
2013.09.10 |
申请号 |
US20080747008 |
申请日期 |
2008.12.01 |
申请人 |
BARBANTI ELENA;FARAVELLI LAURA;SALVATI PATRICIA;CANEVOTTI RENATO;PONZINI FRANCESCO;NEWRON PHARMACEUTICALS, S.P.A. |
发明人 |
BARBANTI ELENA;FARAVELLI LAURA;SALVATI PATRICIA;CANEVOTTI RENATO;PONZINI FRANCESCO |
分类号 |
C07C231/12;A61K31/165;C07C233/09 |
主分类号 |
C07C231/12 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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