发明名称 |
G-protein coupled receptor kinase-5 polymorphism |
摘要 |
The present invention is directed to compositions and methods relating to a G-protein coupled receptor kinase-5 polymorphism. The methods include, for example: detecting enhanced desensitization of the beta adrenergic receptor signaling pathway in an individual, assessing partial protection against heart failure progression in an individual, and assessing an individual's response to beta-blocker therapy. The compositions include polynucleotides or fragments thereof of a nucleotide sequence encoding for a G-protein receptor kinase-5 molecule with a thymine at amino acid position 122 and oligonucleotide primers that hybridize thereto.
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申请公布号 |
US8530160(B2) |
申请公布日期 |
2013.09.10 |
申请号 |
US20070440296 |
申请日期 |
2007.09.10 |
申请人 |
DORN GERALD W.;LIGGETT STEPHEN B.;UNIVERSITY OF CINCINNATI |
发明人 |
DORN GERALD W.;LIGGETT STEPHEN B. |
分类号 |
C12Q1/68;C07H21/02;C07H21/04;C12P19/34 |
主分类号 |
C12Q1/68 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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