| 发明名称 |
METABOLICALLY ENGINEERED BACTERIAL STRAINS HAVING ENHANCED 2-KETO-D-GLUCONATE ACCUMULATION |
| 摘要 |
The present invention relates to a method of altering bacterial host cells to accumulate 2-keto-D-gluconic acid (2-KDG) by inactivating an endogenous membrane bound 2-keto-D-gluconate dehydrogenase (2-KDGDH), which prior to inactivation catalyzed the conversion of 2-KDG to 2,5-diketogluconate (2,5-DKG). |
| 申请公布号 |
CA2533936(C) |
申请公布日期 |
2013.09.10 |
| 申请号 |
CA20042533936 |
申请日期 |
2004.07.27 |
| 申请人 |
GENENCOR INTERNATIONAL, INC. |
发明人 |
DODGE, TIMOTHY C.;VALLE, FERNANDO;RASHID, M. HARUNUR |
| 分类号 |
C12P1/00;C07H21/04;C12N;C12N1/21;C12N9/04;C12N15/74;C12P1/04;C12P7/00;C12P7/26;C12P7/58;C12P7/60;C12P19/02 |
主分类号 |
C12P1/00 |
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