AMINOTRIAZOLE DERIVATIVES AS ALX AGONISTS

摘要

FIELD: medicine, pharmaceutics.SUBSTANCE: described are novel aminitriazole derivatives of formula(I), where A is phenyl, heterocyclyl or propan-1,3-diyl; E is *-Calkyl-O-, -CH=CH- or, where asterisks stand for bond, through which binding with R; Q- O or S occurs; Ris hydrogen, Calkyl, cyclopropyl, Calkoxy-Calkyl, benzyl or -CHCHC(O)O-tert-Bu; Ris pyridyl or phenyl, possibly substituted with halogen, Calkyl, Calkoxy, Cfluoroalkyl, Cfluoroalkoxy, di-( Calkyl)amino or Calkoxy-Calkyl; and Ris -CO-Calkyl,-CF-Calkyl or -SO-Calkyl; or their pharmaceutically acceptable salts, pharmaceutical composition, which contains them.EFFECT: obtaining novel compounds for treatment of inflammatory disease or Alzheimer's disease.20 cl, 105 ex, 1 tbl