COMPOSITION AND METHOD FOR SHORT INTERFERING NUCLEIC ACID INHIBITION OF Nav1.8

摘要

PROBLEM TO BE SOLVED: To provide a method for treating pain.SOLUTION: There are provided short interfering nucleic acids, either single-stranded or double-stranded, which cause RNAi-induced degradation of mRNA from a Na1.8 sodium channel gene; pharmaceutical compositions comprising such short interfering nucleic acids; recombinant vectors comprising such short interfering nucleic acids; a method for inhibiting translation of an mRNA; a method for inhibiting expression of a polypeptide; a method for blocking membrane potential in a cell; a method for blocking a sodium current in a cell; and a method for inhibiting chronic pain.