VEGF ANALOG AND METHOD OF USE

摘要

PROBLEM TO BE SOLVED: To provide modified VEGF proteins that inhibit VEGF-mediated activation or proliferation of endothelial cells.SOLUTION: Modified VEGF proteins that inhibit VEGF-mediated activation or proliferation of endothelial cells are provided. The analogs can be used to inhibit VEGF-mediated activation of endothelial cells in angiogenesis-associated diseases such as cancer, inflammatory diseases, eye diseases and skin disorders.