| 摘要 |
PROBLEM TO BE SOLVED: To provide a novel compound inhibiting an AKT protein kinase.SOLUTION: The present invention provides compounds containing a resolved enantiomer, a resolved diastereomer, a solvate and a pharmaceutically acceptable salt thereof, including formula (I). A method of using the compound is also provided to treat a hyperproliferative disease such as a cancer, as an AKT protein kinase inhibitor. In one embodiment, the invention provides a method of inhibiting production of an AKT protein kinase in a mammal animal, and of including the step of administering, to the mammal animal, the compound of formula I, the enantiomer, the solvate, a metabolite, or a pharmaceutically acceptable salt or a prodrug thereof, in an amount effective to inhibit the production of the AKT protein kinase. |
