发明名称 |
Stabil, isotonisk lyofiliseret proteinformulering |
摘要 |
A stable lyophilized protein formulation is described which can be reconstituted with a suitable diluent to generate a high protein concentration reconstituted formulation which is suitable for subcutaneous administration. For example, anti-IgE and anti-HER2 antibody formulations have been prepared by lyophilizing these antibodies in the presence of a lyoprotectant. The lyophilized mixture thus formed is reconstituted to a high protein concentration without apparent loss of stability of the protein. |
申请公布号 |
DK1516628(T3) |
申请公布日期 |
2013.09.08 |
申请号 |
DK20040022777T |
申请日期 |
1996.07.23 |
申请人 |
GENENTECH, INC. |
发明人 |
ANDYA, JAMES;CLELAND, JEFFREY L.;HSU, CHUNG C.;SHIRE, STEVEN J.;YANG, JANET YU-FENG;WU, SYLVIA SAU-YAN;LAM, XANTHE M.;OVERCASHIER, DAVID E. |
分类号 |
A61K38/00;A61K39/00;A61K39/395;C07K1/00 |
主分类号 |
A61K38/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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