PERCUTANEOUS ABSORPTION PREPARATION CONTAINING DONEPEZIL, AND METHOD FOR PREPARING SAME

摘要

The present invention relates to a percutaneous absorption preparation such as one provided in the form of a patch, and to a method for preparing same, wherein the percutaneous absorption preparation has a double-layer structure including an adhesive layer and a matrix layer containing a drug which is formulated with an adhesive after completely dissolving donepezil using a specific polymer. According to the present invention, the percutaneous absorption preparation does not exhibit the eduction of donepezil within the preparation, and can release donepezil at a constant rate for a long time, as well as prevent the release dumping phenomenon that occurs in a percutaneous absorption preparation having a single-layer structure.