| 摘要 |
Provided are a preparation method of (R) - praziquantel and an intermediate thereof. 1-alkylcarbamoyl-3,4-dihydroisoquinoline or 1-ester-3,4-dihydroisoquinoline are used as starting materials of the preparation method; the starting material is reduced and subjected to an enzyme catalyzed enantioselective hydrolysis to give 1-carboxy-1,2,3,4-tetrahydroisoquinoline; the target product is then prepared via a conventional method. The purity of (R) - praziquantel prepared by the method can be above 98%. |
