ENZYMATIC SYNTHESIS OF AMINO ACID AND PEPTIDE C-TERMINAL AMIDES

摘要

Method for enzymatically synthesising an amino acid or peptide C-terminal amide, from the corresponding N-protected amino acid ammonium salt or optionally N-protected peptide C-terminal carboxylic acid ammonium salt, by contacting said N-protected amino acid ammonium salt or optionally N- protected peptide C-terminal carboxylic acid ammonium salt with a serine endopeptidase. in an organic solvent or an organic solvent mixture containing 1 vol% or less water.