| 摘要 |
The present invention relates to a composition for treating, alleviating, or preventing cardiovascular diseases. The cardiovascular diseases can be hypertension or hypertensive cardiac disorders. In addition, the present invention relates to a composition for inhibiting epoxide hydrolase. A Rhizoma Nardostachysis extract, which is one of active ingredients of the present invention, remarkably alleviates or prevents cardiovascular diseases due to excellent soluble epoxide hydrolase inhibitory effects and remarkable NO generation inhibitory effects, and is excellent for having no side effects since a natural substance is contained as an active ingredient. Further, a compound isolated from a Rhizoma Nardostachysis extract among active ingredients of the present invention shows remarkable NO generation inhibitory effects and inhibits epoxide hydrolase to be able to inhibit the hydrolysis of an epoxy fatty acid intermediate such as epoxyeicosatrienoic acids (EETs) which is associated with hypertension, and thus can exhibit effectiveness for treating or preventing cardiovascular diseases, including an antihypertensive effect. |
