发明名称 |
RHOGEF12 IS A THERAPEUTIC TARGET FOR THE TREATMENT OF HEART FAILURE |
摘要 |
The present invention relates to an inhibitor of the Rho guanine nucleotide exchange factor 12 (RhoGEF12) or an inhibitor of an activator of RhoGEF12 for use in the prevention and/or treatment of heart failure associated with cardiac hypertrophy and/or cardiac fibrosis and diseases associated therewith. Further, it relates also a method of treatment and methods for identifying inhibitors of Rho guanine nucleotide exchange factor 12 (RhoGEF12) or inhibitors of an activator of RhoGEF12. |
申请公布号 |
WO2013128025(A1) |
申请公布日期 |
2013.09.06 |
申请号 |
WO2013EP54221 |
申请日期 |
2013.03.01 |
申请人 |
MAX-PLANCK-GESELLSCHAFT ZUR FOERDERUNG DER WISSENSCHAFTEN E.V. |
发明人 |
TAKEFUJI, MIKITO;WETTSCHURECK, NINA;OFFERMANNS, STEFAN |
分类号 |
C12N15/113;A01K67/027;A61K31/713 |
主分类号 |
C12N15/113 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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