PHARMACEUTICAL COMPOSITION PRODUCING HUMAN LACTOFERRIN, METHOD FOR PRODUCING SAID COMPOSITION AND TREATMENT METHOD

摘要

The invention relates to the field of medicine and concerns a pharmaceutical composition in which the treatment effect is produced as a result of the action of the antioxidant, antimicrobial and antitoxic human lactoferrin protein and which comprises non-replicating nanoparticles based on the genome of human adenovirus serotype 5 with a human lactoferrin gene insert, said nanoparticles expressing human lactoferrin in an organism in an amount of not less than 2.33s1011 physical particles per ml of buffer, and a formulating buffer. The method for producing the composition comprises inoculating a permissive cell culture with 293 non-replicating nanoparticles having the human lactoferrin gene, cultivating the culture, subjecting the latter to multi-stage purification and adding the formulating buffer. The treatment method comprises administering the composition in a therapeutically effective dose of 7s1011 to 7s1013 physical particles in a glucose solution to a person in two successive stages, twenty-four hours apart.