发明名称 |
MICROORGANISMS FOR THE PRODUCTION OF MELATONIN |
摘要 |
Recombinant microbial cells and methods for producing melatonin and related compounds using such cells are described. More specifically, the recombinant microbial cell may comprise exogenous genes encoding one or more of an L-tryptophan hydroxylase, a 5-hydroxy-L- tryptophan decarboxylyase, a serotonin acetyltransferase, an acetylserotonin O- methyltransferase; an L-tryptophan decarboxy-lyase, and a tryptamine-5-hydroxylase, and means for providing tetrahydrobiopterin (THB). Related sequences and vectors for use in preparing such recombinant microbial cells are also described. |
申请公布号 |
WO2013127915(A1) |
申请公布日期 |
2013.09.06 |
申请号 |
WO2013EP54019 |
申请日期 |
2013.02.28 |
申请人 |
DANMARKS TEKNISKE UNIVERSITET |
发明人 |
KNIGHT, ERIC MICHAEL;ZHU, JIANGFENG;FOERSTER, JOCHEN;LUO, HAO |
分类号 |
C12N1/21;C12N9/00;C12N9/02;C12N9/04;C12N9/06;C12N9/10;C12N9/78;C12N9/88;C12N15/53;C12N15/54;C12N15/55;C12N15/60;C12P13/22;C12P17/10;C12P17/16;C12P17/18 |
主分类号 |
C12N1/21 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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