METHODS AND KITS FOR PREDICTING THE RESPONSIVENESS OF HEPATOCELLULAR CARCINOMA PATIENTS TO 5-FLUOROURACIL-BASED COMBINATION CHEMOTHERAPY

摘要

Disclosed herein is a method for identifying single nucleotide polymorphisms of a target nucleic acid for predicting whether a patient suffering from hepatocellular carcinoma will respond to a 5-fluorouracil (5-FU)-based combination chemotherapy. In some embodiments, biological sample derived from the patient is processed to determine the presence of a T/T genotype of rs9679162 GALNT14 gene. The presence of the above-identified genotype is an indication that the patient is responsive to the 5-FU-based combination chemotherapy.