发明名称 |
SUPERPARAMAGNETIC NANOPARTICLES WITH PEG SUBSTITUTED alpha-HYDROXY PHOSPHONATE SHELLS |
摘要 |
The present application discloses nanoparticles, particularly nanoparticles of superparamagnetic iron oxide, which find utility in iron therapy and diagnostic imaging such as magnetic resonance (MR). The disclosed nanoparticles have been treated with an alpha-hydroxyphosphonic acid conjugate containing polyethylene glycol as a hydrophilic moiety to render the nanoparticles sufficiently hydrophilic to find utility in diagnostic imaging. Among the modified hydrophilic nanoparticles disclosed are those in which the hydrophilic moieties of the modifying conjugate are polyethylene oxide-based polymers and have a molecular weight greater than 5,000 dalton and less than or equal to about 30,000 daltons. Surprisingly, these nanoparticles have a more rapid and complete processing in liver of retained nanoparticles when compared to similar nanoparticles in which the PEG-based hydrophilic moiety has a molecular weight less than 5,000.
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申请公布号 |
US2013230463(A1) |
申请公布日期 |
2013.09.05 |
申请号 |
US201213411004 |
申请日期 |
2012.03.02 |
申请人 |
HAY BRUCE ALLAN;MEYER DANIEL EUGENE;BALES BRIAN CHRISTOPHER;LUTTRELL MICHAEL TODD;GENERAL ELECTRIC COMPANY |
发明人 |
HAY BRUCE ALLAN;MEYER DANIEL EUGENE;BALES BRIAN CHRISTOPHER;LUTTRELL MICHAEL TODD |
分类号 |
A61K49/18;A61K31/662;B32B5/16;B82Y5/00;B82Y99/00;C07F9/40 |
主分类号 |
A61K49/18 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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