Processes for the preparation of (S)-1-(3-ethoxy-4-methoxyophenyl)-2-methanesulfonylethylamine

摘要

PROCESSES FOR THE PREPARATION OF (S)-1-(3-ETHOXY-4 METHOXYPHENYL)-2-METHANESULFONYLETHYLAMINE Provided herein are new processes for the preparation of aminosulfone intermediates for the synthesis of 2-[1-(3-ethoxy-4-methoxyphenyl)-2-methylsulfonylethyl]-4 acetylaminoisoindoline-1,3-dione, which is useful for preventing or treating diseases or conditions related to an abnormally high level or activity of TNF-a. Further provided herein are processes for the commercial production of (S)- 1 -(3 -ethoxy-4-methoxyphenyl)-2 methanesulfonylethylamine. - 41 ATI-2549224vl