FOOT AND MOUTH DISEASE VIRUS WITH INCREASED STABILITY AND ITS USE AS VACCINE

摘要

The present invention provides a foot and mouth disease (FMD) virus having improved stability compared to the field isolate of the same subtype, wherein the virus comprises one or more amino acid mutations along a line of symmetry of the capsid structure. The present invention also relates to a vaccine comprising such an FMD virus and its use to prevent foot and mouth disease.