发明名称 |
Treating stroke and other diseases without inhibiting N-type calcium channels |
摘要 |
The invention provides methods for treating stroke and compositions for use in the same. The methods employ a chimeric peptide pf an active peptide and an internalization peptide. The internalization peptide is a tat variant that promotes uptake of itself and a linked active peptide into a cell without substantial binding to N-type calcium channels. Use of the tat variant allows treating of stroke free of certain side effects associated with binding to N-type calcium channels. Tat variant peptides can also be linked to other active agent for use in treating other diseases. |
申请公布号 |
AU2008223469(B2) |
申请公布日期 |
2013.09.05 |
申请号 |
AU20080223469 |
申请日期 |
2008.02.29 |
申请人 |
NONO INC. |
发明人 |
BELMARES, MICHAEL P.;SALTER, MICHAEL W.;GARMAN, JONATHAN DAVID;LU, PETER S.;TYMIANSKI, MICHAEL |
分类号 |
C07K14/435;A61K38/00;A61K38/04;A61K38/10;A61K38/16 |
主分类号 |
C07K14/435 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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