发明名称 |
Stable amyloid beta monomers and oligomers |
摘要 |
The invention provides monomeric and oligomeric amyloid beta peptide isomers that are resistant towards fibrillogenesis and their use as screening reagents or antigens in methods and pharmaceutical preparations for the treatment of Alzheimer's disease and other conditions related to protein misfolding. The alanines at positions 21 and 30, in wild type amyloid beta peptide amino acid sequence, are according to the invention replaced by cysteins, which results in an intra molecular disulphide bond. The invention further provides transgenic animals expressing modified amyloid precursor proteins or amyloid beta peptides. |
申请公布号 |
AU2009236699(B2) |
申请公布日期 |
2013.09.05 |
申请号 |
AU20090236699 |
申请日期 |
2009.04.14 |
申请人 |
ALZINOVA AB |
发明人 |
SANDBERG, ANDERS;HARD, TORLEIF |
分类号 |
C07K14/47;A61K38/17;A61K39/395;A61P25/28 |
主分类号 |
C07K14/47 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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