| 摘要 |
PROBLEM TO BE SOLVED: To provide a humanized antibody having no immunogenicity while exhibiting a strong binding affinity to a VLA-4 receptor.SOLUTION: A humanized immunoglobulin includes a humanized light chain comprising three complementarity-determining regions having amino acid sequences from the corresponding complementarity-determining regions of the mouse 21.6 immunoglobulin light chain variable domain, and a variable region framework from a human kappa light chain variable region framework sequence, provided that at least one position selected from a first group consisting of L45, L49, L58 and L69 (Kabat numbering convention) is occupied by the same amino acid residue present in the equivalent position of the mouse 21.6 immunoglobulin light chain variable region framework. |
