| 摘要 |
PROBLEM TO BE SOLVED: To provide new particular crystalline forms of 2-methyl-2-[4-(3-methyl-2-oxo-8-quinolin-3-yl-2,3-dihydro-imidazo[4,5-c]quinolin-1- yl)-phenyl]-propionitrile, its hydrates and solvates, its salts and hydrates or solvates of its salts, which exhibit new physical properties for the dissolution of drug substances and/or facilitated routes of manufacturing/purification.SOLUTION: This invention relates to: crystal forms of monohydrate of a compound, crystal forms of monotosylate monohydrate, crystal forms of monotosylate dihydrate, crystal forms of ditosylate, and the like; method of manufacturing them; and pharmaceutical composition containing them. |
