发明名称 CELL PERMEABLE NANOCONJUGATES OF SHELL-CROSSLINKED KNEDEL (SCK) AND PEPTIDE NUCLEIC ACIDS (PNAs) WITH UNIQUELY EXPRESSED OR OVER-EXPRESSED mRNA TARGETING SEQUENCES FOR EARLY DIAGNOSIS AND THERAPY OF CANCER
摘要 A functional biologically active particle conjugate useful for diagnosis and treating cancer as a bioportal comprises a nanoscale particle having associated therewith an intracellular targeting ligand comprising a PNA, or another nuclease resistant oligonucleotide analog such as MOE-mRNA (2'-methoxyethyl mRNA) or LNA (locked nucleic acid), having a sequence that binds selectively to an uniquely expressed or overexpressed mRNA specific to the cancer or disease state in a living mammal. In one aspect the uniquely overexpressed target specific to the cancer or disease state is the unr mRNA which can be targeted by the antisense sequence PNA50.
申请公布号 US2013230452(A1) 申请公布日期 2013.09.05
申请号 US201213705682 申请日期 2012.12.05
申请人 WASHINGTON UNIVERSITY 发明人 BECKER MATTHEW L.;FANG HUAFENG;LI XIAOXU;PAN DIPANJAN;ROSSIN RAFFAELLA;SUN XIANKAI;TAYLOR JOHN STEPHEN;TUMER JEFFREY L.;WELCH MICHAEL JOHN;WOOLEY KAREN L.
分类号 A61K31/7088 主分类号 A61K31/7088
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