发明名称 |
CELL PERMEABLE NANOCONJUGATES OF SHELL-CROSSLINKED KNEDEL (SCK) AND PEPTIDE NUCLEIC ACIDS (PNAs) WITH UNIQUELY EXPRESSED OR OVER-EXPRESSED mRNA TARGETING SEQUENCES FOR EARLY DIAGNOSIS AND THERAPY OF CANCER |
摘要 |
A functional biologically active particle conjugate useful for diagnosis and treating cancer as a bioportal comprises a nanoscale particle having associated therewith an intracellular targeting ligand comprising a PNA, or another nuclease resistant oligonucleotide analog such as MOE-mRNA (2'-methoxyethyl mRNA) or LNA (locked nucleic acid), having a sequence that binds selectively to an uniquely expressed or overexpressed mRNA specific to the cancer or disease state in a living mammal. In one aspect the uniquely overexpressed target specific to the cancer or disease state is the unr mRNA which can be targeted by the antisense sequence PNA50.
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申请公布号 |
US2013230452(A1) |
申请公布日期 |
2013.09.05 |
申请号 |
US201213705682 |
申请日期 |
2012.12.05 |
申请人 |
WASHINGTON UNIVERSITY |
发明人 |
BECKER MATTHEW L.;FANG HUAFENG;LI XIAOXU;PAN DIPANJAN;ROSSIN RAFFAELLA;SUN XIANKAI;TAYLOR JOHN STEPHEN;TUMER JEFFREY L.;WELCH MICHAEL JOHN;WOOLEY KAREN L. |
分类号 |
A61K31/7088 |
主分类号 |
A61K31/7088 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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