发明名称 |
RECOMBINANT SUBUNIT DENGUE VIRUS VACCINE |
摘要 |
The present invention provides dengue virus vaccines and immunogenic compositions for administration to human subjects. The vaccine compositions of the present invention comprise recombinantly produced monomeric and/or dimeric forms of truncated dengue virus envelope glycoprotein that, when formulated together with an adjuvant and a pharmaceutically acceptable carrier, induce balanced tetravalent immune responses. In preferred embodiments of the compositions described herein, the DEN4 protein component is a dimeric form of DEN4. The compositions are designed to be acceptable for use in the general population, including immunosuppressed, immunocompromised, and immunosenescent individuals. Also provided herein are methods of inducing a protective immune response in a human patient population by administering the compositions described herein to the patients. |
申请公布号 |
EP2632485(A1) |
申请公布日期 |
2013.09.04 |
申请号 |
EP20110865332 |
申请日期 |
2011.10.27 |
申请人 |
MERCK SHARP & DOHME CORP. |
发明人 |
COLLER, BETH-ANN GRISWOLD;PAI, VIDYA B.;PARKS, D. ELLIOT;YELMENE, MICHELE;BETT, ANDREW J.;MARTYAK, TIMOTHY |
分类号 |
A61K39/12 |
主分类号 |
A61K39/12 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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