CAPTURE OF METHYLATED RNA AND/OR DNA SEQUENCES BY SPECIFIC PROBES

摘要

The present invention relates to a technology for specific capture of methylated target DNA and/or RNA by a complementary probe comprising one or more intercalator molecules. The method further involves removal of cytosine residues which are not methylated from the target DNA and/or RNA prior to interaction with the complementary probe. This results in generation of one or more abasic sites which can interact with and/or into where the intercalator molecule can be inserted.