<p>The present invention is directed to caprolactams which are positive allosteric modulators of metabotropic glutamate receptors, particularly the mGluR5 receptor, and which are useful in the treatment or prevention of neurological and psychiatric disorders associated with glutamate dysfunction and diseases in which metabotropic glutamate receptors are involved. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which metabotropic glutamate receptors are involved.</p>
申请公布号
EP2632900(A2)
申请公布日期
2013.09.04
申请号
EP20110836906
申请日期
2011.10.24
申请人
MERCK SHARP & DOHME CORP.
发明人
SISKO, JOHN, T.;TUCKER, THOMAS, J.;TYNEBOR, ROBERT, M.