发明名称 |
MULTIMER OF EXTRACELLULAR DOMAIN OF CELL SURFACE FUNCTIONAL MOLECULE |
摘要 |
<p>As a substance which pharmacologically regulates the function of a cell surface functional molecule, a substance which has specificity and an activity or efficacy equal or superior to an antibody and does not require an advanced production technique and facility for application thereof to a pharmaceutical product has been demanded. The invention relates to a multimer of an extracellular domain of a cell surface functional molecule, particularly a tetramer of an extracellular domain of PD-1 or PD-L1. Further, the invention relates to an application of such a tetramer as a preventive and/or therapeutic agent for cancer, cancer metastasis, immunodeficiency, an infectious disease or the like and an application of PD-1 or PD-L1 as a testing or diagnostic agent or a research agent for such a disease.</p> |
申请公布号 |
EP1997887(B1) |
申请公布日期 |
2013.09.04 |
申请号 |
EP20070715146 |
申请日期 |
2007.03.02 |
申请人 |
ONO PHARMACEUTICAL CO., LTD. |
发明人 |
MINATO, NAGAHIRO;TANAKA, YOSHIMASA;SHIBAYAMA, SHIRO |
分类号 |
C07K14/705;A61K9/00;A61K9/19;A61K47/26 |
主分类号 |
C07K14/705 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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