发明名称 |
PHENYLKETONE CARBOXYLATE COMPOUNDS AND PHARMACEUTICAL USES THEREOF |
摘要 |
Phenylketone carboxylate compounds of Formula I, wherein n=2-6; R=C(0); -OC(O)- or -CH(OH)-; A is (CH2)mCOOH, W(CH2)mCOOH or YCH(COOH)((CH2)pCH3) when B is Ft B is (CH2)mCOOH, W(CH2)mCOOH or YCH(COOH)((CH2)pCH3) when A is Ft or A and B form a 5-7 membered cycloalkyl substituted with COOFt W=0, S or NFt Y=0,S,NH or CH2; m=0-2; p=1-7; have been prepared. These compounds and their pharmaceutically acceptable salts have beneficial therapeutic effects to prevent or treat a condition related to (l) blood disorders, (ii) inflammation related diseases, (iii) renal disorders and/or renal disorders complications, or (iv) fibrosis-related organ dysfunction. |
申请公布号 |
EP2632885(A1) |
申请公布日期 |
2013.09.04 |
申请号 |
EP20110835381 |
申请日期 |
2011.10.26 |
申请人 |
PROMETIC BIOSCIENCES INC. |
发明人 |
ZACHARIE, BOULOS;PENNEY, CHRISTOPHER;ABBOTT, SHAUN;GAGNON, LYNE;GROUIX, BRIGITTE;LAURIN, PIERRE;BIENVENU, JEAN-FRANCOIS |
分类号 |
C07C59/90;A61K31/192;A61K31/196;A61K31/222;A61K31/235;C07C59/68;C07C59/84;C07C62/38;C07C65/32;C07C69/92;C07C217/84;C07C229/18;C07C323/20;C07C323/52;C07C323/62 |
主分类号 |
C07C59/90 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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