发明名称 |
3.4 kb mitochondrial DNA deletion for use in the detection of cancer |
摘要 |
A method is described wherein prostate or breast cancer is detected by quantifying a 3.4-kilobase deletion in the mitochondrial DNA (mtDNA) of a test sample. The deletion is located between nucleotides 10744-14124 of the mitochondrial genome. An increase in the amount of the deletion relative to the amount of the deletion in non-cancerous prostate and breast tissue is indicative of prostate and breast cancer, respectively. The deletion is detected by detecting the sublimon, i.e. the re-circularized deleted fragment that corresponds to SEQ ID NO:1. |
申请公布号 |
EP2634267(A1) |
申请公布日期 |
2013.09.04 |
申请号 |
EP20130169334 |
申请日期 |
2007.09.26 |
申请人 |
MITOMICS INC. |
发明人 |
PARR, RYAN;THAYER, ROBERT;DAKUBO, GABRIEL D.;CREED, JENNIFER;ROBINSON, KERRY;MAGGRAH, ANDREA;REGULY, BRIAN |
分类号 |
C12Q1/68;C12N15/10;C12N15/11 |
主分类号 |
C12Q1/68 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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