发明名称 |
Substituted cyclohexyl carboxylic acid compounds |
摘要 |
<p>Alcohol derivatives represented by the general formula (IV);
wherein: R 1 represents a substituted C 1 -C 12 alkyl group; a substituted C 2 -C 6 alkenyl group; a substituted amino group; a substituted C 1 -C 6 alkoxy group; a substituted C 1 -C 6 alkylthio group; a substituted carbamoyl group; a substituted sulfonamide group; or a substituted amide group; the ring A represents a saturated cyclic alkyl group with 5 to 7 carbon atoms; R 2 represents a hydrogen atom, a substituted or unsubstituted alkyl group, a substituted or unsubstituted aromatic hydrocarbon group or a substituted or unsubstituted heterocyclic group; R 3 represents a hydrogen atom, a group represented by the general formula R 4 O- ; or a group represented by the general formula R 5 (R 6 )N-wherein R 4 represents a hydrogen atom, a substituted or unsubstituted alkyl group, a substituted or unsubstituted aromatic hydrocarbon group or a substituted or unsubstituted heterocyclic group; R 5 and R 6 may be the same or different and each represents a hydrogen atom, a substituted or unsubstituted alkyl group, a substituted or unsubstituted aromatic hydrocarbon group or a substituted or unsubstituted heterocyclic group, The cyclic carboxylic acid derivatives of formula (IV) are useful for the synthesis of cyclic amide derivatives useful as cathepsin K inhibitors.</p> |
申请公布号 |
EP1616859(B1) |
申请公布日期 |
2013.09.04 |
申请号 |
EP20050018361 |
申请日期 |
1999.11.12 |
申请人 |
SEIKAGAKU CORPORATION |
发明人 |
HOSODA, AKIHIKO;KOBAYASHI, NOBUO;KOJI, NAOKO;KOJI, TSUNEO;SHIBATA, MASAHIRO;SEKINE, AKIHIRO;DOZEN, MASAHARU |
分类号 |
C07C211/00;C07C307/08;A61K31/19;A61K31/36;A61K31/4406;A61K31/445;A61K31/47;A61K31/495;A61K31/5375;A61K31/54;A61K31/551;A61P19/02;C07C271/24;C07C275/26;C07C311/20;C07C311/29;C07C311/46;C07C317/44;C07C323/60;C07D211/62;C07D213/71;C07D213/75;C07D215/36;C07D223/12;C07D231/40;C07D243/08;C07D277/48;C07D277/68;C07D295/205;C07D295/215;C07D295/26;C07D295/32;C07D307/14;C07D307/33;C07D307/52;C07D309/20;C07D317/28;C07D317/46;C07D317/58;C07D317/66;C07D317/68;C07D317/72;C07D319/06 |
主分类号 |
C07C211/00 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|