ANTIBODIES WHICH BIND SOLUBLE T-CELL RECEPTOR LIGANDS
摘要
Provided are isolated high affinity entities which comprise an antigen binding domain which specifically binds a soluble T-cell receptor ligand comprising a two-domain beta1-alpha1 of a major histocompatibility complex (MHC) class II, wherein said antigen binding domain does not bind a complex comprising a four-domain alpha1-beta1/alpha2-beta2 MHC class II. Also provided are methods and kits using same for detecting and sequestering soluble two-domain T cell receptor ligands in a sample.
申请公布号
EP2632955(A1)
申请公布日期
2013.09.04
申请号
EP20110799821
申请日期
2011.10.26
申请人
TECHNION RESEARCH & DEVELOPMENT FOUNDATION LTD.;THE UNITED STATES GOVERNMENT AS REPRESENTED BY THE DEPARTMENT OF VETERANS AFFAIRS