Vaccine constructs and combinations of vaccines designed to improve the breadth of the immune response to diverse strains and clades of HIV

摘要

The present disclosure provides compositions for eliciting an immune response, including a prophylactic immune response, against human immunodeficiency virus. The composition includes nucleic acid constructs encoding HIV antigenic polypeptides of multiple clades or strains. Methods for eliciting an immune response by administering the composition to a subject are also provided.