发明名称 |
APOPTOSIS IMAGING AGENTS BASED ON LANTIBIOTIC PEPTIDES |
摘要 |
The present invention relates to radiopharmaceutical imaging in vivo of apoptosis. The invention provides imaging agents which target apoptotic cells via selective binding to the aminophospholipid phosphatidylethanolamine (PE), which is exposed on the surface of apoptotic cells. The radiopharmaceuticals comprise radiometal complexes of chelator conjugates of PE-binding peptides. Also provided are pharmaceutical compositions, kits and methods of in vivo imaging.
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申请公布号 |
KR20130097780(A) |
申请公布日期 |
2013.09.03 |
申请号 |
KR20137010727 |
申请日期 |
2011.09.27 |
申请人 |
GE HEALTHCARE LIMITED |
发明人 |
INDREVOLL BARD;HISCOCK DUNCAN;ARBO BENTE ELIZABETH;BHALLA RAJIV;GLASER MATTHIAS EBERHARD;MCROBBIE GRAEME WALTER |
分类号 |
A61K49/04;A61K51/08;A61K103/10 |
主分类号 |
A61K49/04 |
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